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What is cancer tumor infiltrating lymphocyte?
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- cancer tumor infiltrating lymphocyte
Tumor infiltrating lymphocyte is a white blood cell that has left the bloodstream and migrated into a tumor. Tumor is an abnormal mass of tissue that results when cells divide more than they should or do not die when they should. Tumors may be benign (not cancer), or malignant (cancer). Also called neoplasm. Lymphocyte is a type of immune cell that is made in the bone marrow and is found in the blood and in lymph tissue. The two main types of lymphocytes are B lymphocytes and T lymphocytes. B lymphocytes make antibodies, and T lymphocytes help kill tumor cells and help control immune responses. A lymphocyte is a type of white blood cell. Cancer is a term for diseases in which abnormal cells divide without control and can invade nearby tissues. Cancer cells can also spread to other parts of the body through the blood and lymph systems. There are several main types of cancer. Carcinoma is a cancer that begins in the skin or in tissues that line or cover internal organs. Sarcoma is a cancer that begins in bone, cartilage, fat, muscle, blood vessels, or other connective or supportive tissue. Leukemia is a cancer that starts in blood-forming tissue such as the bone marrow, and causes large numbers of abnormal blood cells to be produced and enter the blood. Lymphoma and multiple myeloma are cancers that begin in the cells of the immune system. Central nervous system cancers are cancers that begin in the tissues of the brain and spinal cord. Also called malignancy.
Preview- It has been discovered that, tumor infiltrating lymphocytes an intriguing player in the survival of colorectal cancer patients BMC Immunology. Immunology is the study of the body`s immune system. Colorectal cancer, cancer that develops in the colon (the longest part of the large intestine) and/or the rectum (the last several inches of the large intestine before the anus). Colorectal, having to do with the colon or the rectum.
- Evidently, the positive impact of tumor infiltrating lymphocytes on overall survival was lost and only early stage (p < 0.001) and young age (p = 0.04) were independently associated with a better overall survival. For disease-free survival, early stage (p < 0.001) was the only independent factor associated with a better outcome (table (table33). Stage is the extent of a cancer in the body. Staging is usually based on the size of the tumor, whether lymph nodes contain cancer, and whether the cancer has spread from the original site to other parts of the body. Overall survival is the length of time from either the date of diagnosis or the start of treatment for a disease, such as cancer, that patients diagnosed with the disease are still alive. In a clinical trial, measuring the overall survival is one way to see how well a new treatment works. Also called OS. Outcome is a specific result or effect that can be measured. Examples of outcomes include decreased pain, reduced tumor size, and improvement of disease.
- One can view, when entered into a multiple Cox regression analysis adjusting for other possible important confounding factors, only early stage and young age (borderline significant for overall population only) were associated with a better overall survival (early stage also with disease-free survival). The beneficial effect of tumor infiltrating lymphocytes in colorectal cancer could not be confirmed in the Cox regression survival analysis. Regression is a decrease in the size of a tumor or in the extent of cancer in the body. Analysis is a process in which anything complex is separated into simple or less complex parts. Significant is in statistics, describes a mathematical measure of difference between groups. The difference is said to be significant if it is greater than what might be expected to happen by chance alone. Also called statistically significant.
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