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What is cancer BL22 immunotoxin?
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- cancer bl immunotoxin
Preview- It is clear that, immunotoxins are chimeric proteins with a cell-selective ligand chemically linked or genetically fused to a toxin moiety and can target (i.e., target organ) cancer cells overexpressing tumor (i.e., neoplasm)-associated antigens, membrane (i.e., biomembrane, or membrana) receptors, or carbohydrate antigens. Membrane is a very thin layer (i.e., panniculus) of tissue that covers a surface (i.e., face, or facies). Tumor is an abnormal mass of tissue that results when cells divide more than they should or do not die when they should. Tumors may be benign (not cancer), or malignant (cancer). Also called neoplasm (i.e., new growth, or tumor). Chimeric, having parts of different origins. In medicine, refers to a person, organ, or tissue that contains cells with different genes than the rest of the person, organ, or tissue. This may happen because of a mutation (genetic change) that occurs during development, or as a result of a transplant of cells, organs, or tissues from another person or from a different species. In the laboratory, a chimeric protein can be made by combining two different genes. For example, a chimeric antibody is made by joining antibody genes from two different species, such as human and mouse. Cell is the individual unit
that makes up the tissues of the body. All living things are made up of one or more cells. Carbohydrate is a sugar molecule. Carbohydrates can be small and simple (for example, glucose) or they can be large and complex (i.e., sequence) (for example, polysaccharides such as starch (i.e., amylum), chitin or cellulose (i.e., cellulin)).
It`s possible to conclude that, the immunotoxin binds to the malignant neoplastic disease cell by means of its targeting domain and undergoes internalization.
One can recognize, a promising strategy that has been developed uses TRAIL (i.e., apo-2l)-based immunotoxins that target cancer cells overexpressing growth factor (i.e., gene) receptors and bring about the bystander outcome. Growth factor is a substance made by the body that functions to regulate cell division (i.e., divisio) and cell survival. Some growth factors are also produced in the laboratory and used in biological therapy (i.e., therapeusis, or therapia). TRAIL is a cell protein that can attach to certain molecules in some cancer cells and may kill the cells. TRAIL is being studied in the treatment of cancer. Also called Apo-2L (i.e., trail), TNF-related apoptosis (i.e., programmed cell death)-inducing ligand, and tumor necrosis factor-related apoptosis-inducing ligand.
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