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How to Find a Colon and Rectal Cancer Treatment Trial
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- find colon
Colon is the longest part of the large intestine, which is a tube-like organ connected to the small intestine at one end and the anus at the other. The colon removes water and some nutrients and electrolytes from partially digested food. The remaining material, solid waste called stool, moves through the colon to the rectum and leaves the body through the anus.
Preview- It`s possible to presume that, refractory metastatic colorectal cancer is an all too common situation for patients and caregivers. The search for available clinical trialscan be confusing and frustrating for many patients. This website is designed to provide some guidance to patients looking for clinical trials of novel agentsthat may provide benefit, and help in deciphering the terminology of clinical trials, including definitions of Phase I, IB, II, IIB, and III trials . First, some definitions. Colorectal cancer is a broad term that includes patients with colon cancer or rectal cancer. Although the treatments for early stage disease is different for colon and rectal cancer, they share very similar biology and are commonly treated as one entity when the disease is metastatic.Metastatic disease refers to cancer that has spread to distant regions of the body, most commonly to the liver, lungs, or abdominal lining (peritoneum).When cancer that starts in the colon or rectumspreads to other locations, the cancer is stillcalled colorectal cancer, and is not called by the name of its metastatic location. For example, colorectal cancer that spreads to the liver is called metastatic colorectal cancer. It is not called liver cancer, which is a separate type of cancer withvery different treatments. Patients who have previously been treated with the available chemotherapy agents and had the disease grow in size despite treatment are considered to have refractory cancer. This website is specifically designed to keep an updated list of available Phase II studiesfor patients whose colorectal cancer is refractory to all available FDA (Food and Drug Administration)-approved agents, accessibly by from the links above. Frequently Asked Questions What are the FDA (Food and Drug Administration) approved agents for metastatic colorectal cancer? Abdominal, having to do with the abdomen, which is the part of the body between the chest and the hips that contains the pancreas, stomach, intestines, liver, gallbladder, and other organs. Refractory is in medicine, describes a disease or condition that does not respond to treatment. Metastatic, having to do with metastasis, which is the spread of cancer from the primary site (place where it started) to other places in the body. Colorectal, having to do with the colon or the rectum. Colorectal cancer, cancer that develops in the colon (the longest part of the large intestine) and/or the rectum (the last several inches of the large intestine before the anus). Liver cancer, primary liver cancer is cancer that forms in the tissues of the liver. Secondary liver cancer is cancer that spreads to the liver from another part of the body. Peritoneum is the tissue that lines the abdominal wall and covers most of the organs in the abdomen. Refractory cancer, cancer that does not respond to treatment. The cancer may be resistant at the beginning of treatment or it may become resistant during treatment. Also called resistant cancer. ALL is an aggressive (fast-growing) type of leukemia (blood cancer) in which too many lymphoblasts (immature white blood cells) are found in the blood and bone marrow. Also called acute lymphoblastic leukemia and acute lymphocytic leukemia. Stage is the extent of a cancer in the body. Staging is usually based on the size of the tumor, whether lymph nodes contain cancer, and whether the cancer has spread from the original site to other parts of the body. Chemotherapy, treatment with drugs that kill cancer cells. FDA is an agency in the U.S. federal government whose mission is to protect public health by making sure that food, cosmetics, and nutritional supplements are safe to use and truthfully labeled. The FDA also makes sure that drugs, medical devices, and equipment are safe and effective, and that blood for transfusions and transplant tissue are safe. Also called Food and Drug Administration. Liver is a large organ located in the upper abdomen. The liver cleanses the blood and aids in digestion by secreting bile. Clinical, having to do with the examination and treatment of patients.
- Apparently, the most up to date resource for this is the website maintained by the National Cancer Institute, ClinicalTrials.gov. However, many patients find this site difficult to navigate and lacking sufficient information to critically judge the available trials. For more information, see our guide tointerpreting ClinicalTrials.gov. Once you have identified some potential trials, look though our guide to evaluating a clinical trial . When should I consider enrolling in a clinical trial? There are clinical trials available for adjuvant therapy for colon and rectal cancer, as well as initial therapy and second-line therapy for metastatic colorectal cancer. If such trials are available to you, you should consider enrolling in them, as they provide access to the latest potential advances in the field and additional research nurse involvement in your care that would not otherwise be available. However, after a patient`s cancer grows, it is not uncommon for there to be limited treatment options available. In this situation, clinical trials may be the only available option for treating your disease. Given the effort likely to be involved in traveling to a specialized center for such trials, it is important that patients understand the options available to them. This website is designed to be one such tool that can be used with your oncologist to formulate the best plan for your treatment. However, clinical trials are not the right option for all patients, and your oncologist can help discuss the risks and benefits of this. Adjuvant therapy, additional cancer treatment given after the primary treatment to lower the risk that the cancer will come back. Adjuvant therapy may include chemotherapy, radiation therapy, hormone therapy, targeted therapy, or biological therapy. Oncologist is a doctor who specializes in treating cancer. Some oncologists specialize in a particular type of cancer treatment. For example, a radiation oncologist specializes in treating cancer with radiation. Second-line therapy, treatment that is given when initial treatment (first-line therapy) doesn`t work, or stops working. Nurse is a health professional trained to care for people who are ill or disabled. National Cancer Institute is the National Cancer Institute, part of the National Institutes of Health of the United States Department of Health and Human Services, is the Federal Government`s principal agency for cancer research. The National Cancer Institute conducts, coordinates, and funds cancer research, training, health information dissemination, and other programs with respect to the cause, diagnosis, prevention, and treatment of cancer. Access the National Cancer Institute Web site at http://www.cancer.gov. Also called NCI.
- Finally, one can assume that, colon cancer sometimes is treated differently from rectal cancer. Treatments for colon and rectal cancer are described separately below.
- rectal cancer treatment trial
Rectal, by or having to do with the rectum. The rectum is the last several inches of the large intestine closest to the anus. Rectal cancer, cancer that forms in the tissues of the rectum (the last several inches of the large intestine closest to the anus). Cancer is a term for diseases in which abnormal cells divide without control and can invade nearby tissues. Cancer cells can also spread to other parts of the body through the blood and lymph systems. There are several main types of cancer. Carcinoma is a cancer that begins in the skin or in tissues that line or cover internal organs. Sarcoma is a cancer that begins in bone, cartilage, fat, muscle, blood vessels, or other connective or supportive tissue. Leukemia is a cancer that starts in blood-forming tissue such as the bone marrow, and causes large numbers of abnormal blood cells to be produced and enter the blood. Lymphoma and multiple myeloma are cancers that begin in the cells of the immune system. Central nervous system cancers are cancers that begin in the tissues of the brain and spinal cord. Also called malignancy.
Preview- As an example, chemoradiation Since the NSABP Protocol R-01 trial(15) had found a survival benefit for postoperative chemotherapy in rectal cancer patients, investigators began pursuing adjuvant treatment regimens using radiation plus chemotherapy in order to reduce both local recurrence and increase survival. Both the GITSG(14) and NCCTG 794751(16) trials reported a decrease in local recurrence rates (14% vs. Protocol is a detailed plan of a scientific or medical experiment, treatment, or procedure. In clinical trials, it states what the study will do, how it will be done, and why it is being done. It explains how many people will be in the study, who is eligible to take part in it, what study drugs or other interventions will be given, what tests will be done and how often, and what information will be collected. Chemotherapy, treatment with drugs that kill cancer cells. Recurrence, cancer that has recurred (come back), usually after a period of time during which the cancer could not be detected. The cancer may come back to the same place as the original (primary) tumor or to another place in the body. Also called recurrent cancer. Chemoradiation, treatment that combines chemotherapy with radiation therapy. Also called chemoradiotherapy. Postoperative, after surgery.
- It`s possible to observe, this review will update the current role of adjuvant therapy for colon and rectal cancer. Colon is the longest part of the large intestine, which is a tube-like organ connected to the small intestine at one end and the anus at the other. The colon removes water and some nutrients and electrolytes from partially digested food. The remaining material, solid waste called stool, moves through the colon to the rectum and leaves the body through the anus. Adjuvant therapy, additional cancer treatment given after the primary treatment to lower the risk that the cancer will come back. Adjuvant therapy may include chemotherapy, radiation therapy, hormone therapy, targeted therapy, or biological therapy.
- It is often discovered that, national Institutes of Health (NIH) consensus development conference statement adjuvant therapy for patients with colon and rectal cancer. National Institutes of Health is a federal agency in the U.S. that conducts biomedical research in its own laboratories; supports the research of non-Federal scientists in universities, medical schools, hospitals, and research institutions throughout the country and abroad; helps in the training of research investigators; and fosters communication of medical information. Access the National Institutes of Health Web site at http://www.nih.gov. Also called NIH.
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