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Cancer - What is Drug Metabolism SNPs
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- cancer drug metabolism snps
Metabolism is the chemical changes that take place in a cell or an organism. These changes make energy and the materials cells and organisms need to grow, reproduce, and stay healthy. Metabolism also helps get rid of toxic substances. SNP is the most common type of change in DNA (molecules inside cells that carry genetic information). SNPs occur when a single nucleotide (building block of DNA) is replaced with another. These changes may cause disease, and may affect how a person reacts to bacteria, viruses, drugs, and other substances. Also called single nucleotide polymorphism. Cancer is a term for diseases in which abnormal cells divide without control and can invade nearby tissues. Cancer cells can also spread to other parts of the body through the blood and lymph systems. There are several main types of cancer. Carcinoma is a cancer that begins in the skin or in tissues that line or cover internal organs. Sarcoma is a cancer that begins in bone, cartilage, fat, muscle, blood vessels, or other connective or supportive tissue. Leukemia is a cancer that starts in blood-forming tissue such as the bone marrow, and causes large numbers of abnormal blood cells to be produced and enter the blood. Lymphoma and multiple myeloma are cancers that begin in the cells of the immune system. Central nervous system cancers are cancers that begin in the tissues of the brain and spinal cord. Also called malignancy.
Preview- One can determine, the seven SNPs of folate and drug metabolizing pathway genes, namely MTHFD1 G1958. A (rs2236225), TYMS 3. R/2. R (rs2236225), SHMT1 C1420. T (rs1979277), MTR A2756. G (rs1805087), MTRR A66. G (rs1801394), CBS T833/844. INS68 and SULT1. A1 G638. A (rs1042028), were analyzed in healthy unrelated south. A6 is a substance being studied in the treatment of cancer. A6 is a small piece of a protein called urokinase (an enzyme that dissolves blood clots or prevents them from forming). It is a type of antiangiogenesis agent and a type of antimetastatic agent. Also called urokinase plasminogen activator (uPA)-derived peptide A6. Folate is a nutrient in the vitamin B complex that the body needs in small amounts to function and stay healthy. Folate helps to make red blood cells. It is found in whole-grain breads and cereals, liver, green vegetables, orange juice, lentils, beans, and yeast. Folate is water-soluble (can dissolve in water) and must be taken in every day. Not enough folate can cause anemia (a condition in which the number of red blood cells is below normal), diseases of the heart and blood vessels, and defects in the brain and spinal cord in a fetus. Folate is being studied with vitamin B12 in the prevention and treatment of cancer. Also called folic acid.
- It`s possible to assume that, to date, no study has been carried out in the south Indian population to determine the frequencies of the MTHFD1, TYMS, SHMT1, MTR, MTRR and SULT1A1 alleles that are important in pharmacogenomics. This study assessed SNPs from genes involved in the biological activity of drug metabolism, DNA synthesis and DNA methlylation. Pharmacogenomics is the study of how a person`s genes affect the way he or she responds to drugs. Pharmacogenomics is being used to learn ahead of time what the best drug or the best dose of a drug will be for a person. Also called pharmacogenetics. Biological, pertaining to biology or to life and living things. In medicine, refers to a substance made from a living organism or its products. Biologicals may be used to prevent, diagnose, treat or relieve of symptoms of a disease. For example, antibodies, interleukins, and vaccines are biologicals. Biological also refers to parents and children who are related by blood.
- You can determine, heterogeneity in patient response to drug treatment is consistently observed across patient populations. In addition, genetic polymorphisms in drug metabolizing enzymes and other molecules are responsible for much of the interindividual differences in the efficacy and toxicity for chemotherapeutic agents. Efficacy, effectiveness. In medicine, the ability of an intervention (for example, a drug or surgery) to produce the desired beneficial effect. Response is in medicine, an improvement related to treatment. Toxicity is the extent to which something is poisonous or harmful. Genetic, inherited; having to do with information that is passed from parents to offspring through genes in sperm and egg cells.
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