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What is cancer p-glycoprotein?
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- cancer p-glycoprotein
P-glycoprotein is a protein that pumps substances out of cells. Cancer cells that have too much p-glycoprotein may not be killed by anticancer drugs. Glycoprotein is a protein that has sugar molecules attached to it. Cancer is a term for diseases in which abnormal cells divide without control and can invade nearby tissues. Cancer cells can also spread to other parts of the body through the blood and lymph systems. There are several main types of cancer. Carcinoma is a cancer that begins in the skin or in tissues that line or cover internal organs. Sarcoma is a cancer that begins in bone, cartilage, fat, muscle, blood vessels, or other connective or supportive tissue. Leukemia is a cancer that starts in blood-forming tissue such as the bone marrow, and causes large numbers of abnormal blood cells to be produced and enter the blood. Lymphoma and multiple myeloma are cancers that begin in the cells of the immune system. Central nervous system cancers are cancers that begin in the tissues of the brain and spinal cord. Also called malignancy.
Preview- It`s possible to assume that, cancer Res 61 14691476|||| Jonker JW, Buitelaar M, Wagenaar E, van der Valk MA, Scheffer GL, Scheper RJ, Plsch T, Kuipers F, Oude Elferink RPJ, Rosing H, Beijnen JH, Schinkel AH (2002) The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria. Breast, glandular organ located on the chest. The breast is made up of connective tissue, fat, and breast tissue that contains the glands that can make milk. Also called mammary gland. Breast cancer, cancer that forms in tissues of the breast, usually the ducts (tubes that carry milk to the nipple) and lobules (glands that make milk). It occurs in both men and women, although male breast cancer is rare.
- It`s apparent that, pretreatment detection of p-glycoprotein has not been found to be a useful tool for predicting response before the initiation of chemotherapy in breast cancers as its expression has not been commonly observed in the untreated breast cancer cell lines [9,14,15]. There are only scattered reports in the literature of extraordinarily high incidence of p-glycoprotein expression in untreated breast cancer specimen and its role in the assessment of pretreatment p-glycoprotein expression for predicting treatment failure [15-19]. Response is in medicine, an improvement related to treatment. Cell is the individual unit that makes up the tissues of the body. All living things are made up of one or more cells. Incidence is the number of new cases of a disease diagnosed each year. Assessment is in healthcare, a process used to learn about a patient`s condition. This may include a complete medical history, medical tests, a physical exam, a test of learning skills, tests to find out if the patient is able to carry out the tasks of daily living, a mental health evaluation, and a review of social support and community resources available to the patient. Chemotherapy, treatment with drugs that kill cancer cells.
- Finally, seemingly, LA JOLLA, CA, March 25, 2009A research team at the Scripps Research Institute has obtained the first glimpse of a protein that keeps certain substances, including many drugs, out of cells. The protein, called P-glycoprotein or P-gp for short, is one of the main reasons cancer cells are resistant to chemotherapy drugs. Understanding its structure may help scientists design more effective drugs.
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