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Cancer - What is induced spontaneously response
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- cancer induced spontaneously response
Response is in medicine, an improvement related to treatment. Cancer is a term for diseases in which abnormal cells divide without control and can invade nearby tissues. Cancer cells can also spread to other parts of the body through the blood and lymph systems. There are several main types of cancer. Carcinoma is a cancer that begins in the skin or in tissues that line or cover internal organs. Sarcoma is a cancer that begins in bone, cartilage, fat, muscle, blood vessels, or other connective or supportive tissue. Leukemia is a cancer that starts in blood-forming tissue such as the bone marrow, and causes large numbers of abnormal blood cells to be produced and enter the blood. Lymphoma and multiple myeloma are cancers that begin in the cells of the immune system. Central nervous system cancers are cancers that begin in the tissues of the brain and spinal cord. Also called malignancy.
Preview- It`s been discovered that, yet, we report here the failure to detect in vivo-primed p53-specific CD8 T cell responses in cancer patients with spontaneous antibodies to p53 as well as in p53-seronegative patients and in healthy donors using our single in vitro sensitization protocol. In contrast, the same protocol frequently detected NY-ESO-1-specific CD8 T cells in NY-ESO-1-seropositive cancer patients in the same study cohort, indicating that natural immunogenicity to induce spontaneous CD8 T cell responses may be different in p53 and NY-ESO-1 even in seropositive patients for these antigens. It was reported that although cyclin B1-specific CD8 T cells became detectable after a single in vitro stimulation, p53-specific CD8 T cells against 6 HLA-A*02 binding short peptides could not be detected in 5 cyclin B1-reactive and 5 non-reactive patients using the same method [39]. Cohort is a group of individuals who share a common trait, such as birth year. In medicine, a cohort is a group that is part of a clinical trial or study and is observed over a period of time. Protocol is a detailed plan of a scientific or medical experiment, treatment, or procedure. In clinical trials, it states what the study will do, how it will be done, and why it is being done. It explains how many people will be in the study, who is eligible to take part in it, what study drugs or other interventions will be given, what tests will be done and how often, and what information will be collected. Cell is the individual unit that makes up the tissues of the body. All living things are made up of one or more cells. In vitro is in the laboratory (outside the body). The opposite of in vivo (in the body). In vivo is in the body. The opposite of in vitro (outside the body or in the laboratory). T cell is a type of white blood cell. T cells are part of the immune system and develop from stem cells in the bone marrow. They help protect the body from infection and may help fight cancer. Also called T lymphocyte and thymocyte. HLA is a type of molecule found on the surface of most cells in the body. HLAs play an important part in the body`s immune response to foreign substances. They make up a person`s tissue type, which varies from person to person. HLA tests are done before a donor stem cell or organ transplant, to find out if tissues match between the donor and the person receiving the transplant. Also called human leukocyte antigen and human lymphocyte antigen.
- It`s that, the detection of antibody responses against many tumor antigens is usually associated with clinically evident tumors, although anti-p53 antibody has been found in asbestosis patients before their diagnosis of cancer [58]. The presence of spontaneously activated p53-specific CD4 T cells in healthy individuals is likely to play an important role in rapid induction of antibody responses after malignant transformation. Antibody is a protein made by plasma cells (a type of white blood cell) in response to an antigen (a substance that causes the body to make a specific immune response). Each antibody can bind to only one specific antigen. The purpose of this binding is to help destroy the antigen. Some antibodies destroy antigens directly. Others
make it easier for white blood cells to destroy the antigen. An antibody is a type of immunoglobulin. Diagnosis is the process of identifying a disease, such as cancer, from its signs and symptoms. Tumor is an abnormal mass of tissue that results when cells divide more than they should or do not die when they should. Tumors may be benign (not cancer), or malignant (cancer). Also called neoplasm. Transformation is in medicine, the change that a normal cell undergoes as it becomes malignant. Malignant, cancerous. Malignant cells can invade and destroy nearby tissue and spread to other parts of the body. Asbestosis is a lung disease caused by breathing in particles of asbestos (a group of minerals that take the form of tiny fibers). Symptoms include coughing, trouble breathing, and chest pain caused by scarring and permanent damage to lung tissue. Asbestosis increases the risk of lung cancer and malignant mesothelioma (cancer found in the lining of the lungs, chest, or abdomen).
Finally, it is obvious that, in February 2003, the US National Cancer Institute (NCI) held a workshop of more than 100 of the worlds leading experts who study pregnancy and breast cancer risk. The experts reviewed human and animal studies that looked at the link between pregnancy and breast cancer risk, including studies of induced and spontaneous abortions. NCI, nCI, part of the National Institutes of Health of the United States Department of Health and Human Services, is the Federal Government`s principal agency for cancer research. It conducts, coordinates, and funds cancer research, training, health information dissemination, and other programs with respect to the cause, diagnosis, prevention, and treatment of cancer. Access the NCI Web site at http://www.cancer.gov. Also called National Cancer Institute. Breast, glandular organ located on the chest. The breast is made up of connective tissue, fat, and breast tissue that contains the glands that can make milk. Also called mammary gland. Breast cancer, cancer that forms in tissues of the breast, usually the ducts (tubes that carry milk to the nipple) and lobules (glands that make milk). It occurs in both men and women, although male breast cancer is rare. Pregnancy is the condition between conception (fertilization of an egg by a sperm) and birth, during which the fertilized egg develops in the uterus. In humans, pregnancy lasts about 288 days. National Cancer Institute is the National Cancer Institute, part of the National Institutes of Health of the United States Department of Health and Human Services, is the Federal Government`s principal agency for cancer research. The National Cancer Institute conducts, coordinates, and funds cancer research, training, health information dissemination, and other programs with respect to the cause, diagnosis, prevention, and treatment of cancer. Access the National Cancer Institute Web site at http://www.cancer.gov. Also called NCI.
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