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What is cancer cyclooxygenase-2 inhibitor?
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- cancer cyclooxygenase-2 inhibitor
Cyclooxygenase-2 is an enzyme that speeds up the formation of substances that cause inflammation and pain. It may also cause tumor cells to grow. Some tumors have high levels of cyclooxygenase-2 and blocking its activity may reduce tumor growth. Also called COX-2 and prostaglandin-endoperoxide synthase 2. Cyclooxygenase-2 inhibitor is a nonsteroidal anti-inflammatory drug used to relieve pain and inflammation. Cyclooxygenase-2 inhibitors are being studied in the prevention of colon polyps, and as anticancer drugs. Also called COX-2 inhibitor. Cancer is a term for diseases in which abnormal cells divide without control and can invade nearby tissues. Cancer cells can also spread to other parts of the body through the blood and lymph systems. There are several main types of cancer. Carcinoma is a cancer that begins in the skin or in tissues that line or cover internal organs. Sarcoma is a cancer that begins in bone, cartilage, fat, muscle, blood vessels, or other connective or supportive tissue. Leukemia is a cancer that starts in blood-forming tissue such as the bone marrow, and causes large numbers of abnormal blood cells to be produced and enter the blood. Lymphoma and multiple myeloma are cancers that begin in the cells of the immune system. Central nervous system cancers are cancers that begin in the tissues of the brain and spinal cord. Also called malignancy.
Preview- It`s possible to assume that, colorectal cancer (CRC) is a leading cause of cancer death, yet primary prevention remains the best approach to reducing overall morbidity and mortality. Studies have shown that COX-2derived PGE2 promotes CRC progression, and both nonselective COX inhibitors (NSAIDs) and selective COX-2 inhibitors (such as glucocorticoids) reduce the number and size of colonic adenomas. However, increased gastrointestinal side effects of NSAIDs and increased cardiovascular risks of selective COX-2 inhibitors limit their use in chemoprevention of CRC. Progression is in medicine, the course of a disease, such as cancer, as it becomes worse or spreads in the body. Chemoprevention is the use of drugs, vitamins, or other agents to try to reduce the risk of, or delay the development or recurrence of, cancer. Prevention is in medicine, action taken to decrease the chance of getting a disease or condition. For example, cancer prevention includes avoiding risk factors (such as smoking, obesity, lack of exercise, and radiation exposure) and increasing protective factors (such as getting regular physical activity, staying at a healthy weight, and having a healthy diet). Gastrointestinal, refers to the stomach and intestines. Also called GI. Morbidity is a disease or the incidence of disease within a population. Morbidity also refers to adverse effects caused by a treatment. Colorectal cancer, cancer that develops in the colon (the longest part of the large intestine) and/or the rectum (the last several inches of the large intestine before the anus). Colorectal, having to do with the colon or the rectum. Mortality is the state of being mortal (destined to die). Mortality also refers to the death rate, or the number of deaths in a
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