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What is cancer crizotinib?
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- cancer crizotinib
Crizotinib is a drug used to treat advanced non-small cell lung cancer that has a mutated (changed) form of a gene called anaplastic lymphoma kinase (ALK). It is also being studied in the treatment of other types of cancer. Crizotinib blocks the protein made by the mutated ALK gene. Blocking this protein may stop the growth and spread of cancer cells. Crizotinib may also prevent the growth of new blood vessels that tumors need to grow. It is a type of tyrosine kinase inhibitor and a type of antiangiogenesis agent. Also called MET tyrosine kinase inhibitor PF-02341066, PF-02341066, and Xalkori. Cancer is a term for diseases in which abnormal cells divide without control and can invade nearby tissues. Cancer cells can also spread to other parts of the body through the blood and lymph systems. There are several main types of cancer. Carcinoma is a cancer that begins in the skin or in tissues that line or cover internal organs. Sarcoma is a cancer that begins in bone, cartilage, fat, muscle, blood vessels, or other connective or supportive tissue. Leukemia is a cancer that starts in blood-forming tissue such as the bone marrow, and causes large numbers of abnormal blood cells to be produced and enter the blood. Lymphoma and multiple myeloma are cancers that begin in the cells of the immune system. Central nervous system cancers are cancers that begin in the tissues of the brain and spinal cord. Also called malignancy.
Preview- One can presume that, lung cancer Pfizers drug for patients with non-small-cell lung cancer, crizotinib, is aimed at a small group of patients whose tumors carry a specific mutation in a gene called ALK. Lung, one of a pair of organs in the chest that supplies the body with oxygen, and removes carbon dioxide from the body. Gene is the functional and physical unit of heredity passed from parent to offspring. Genes are pieces of DNA, and most genes contain the information for making a specific protein. Lung cancer, cancer that forms in tissues of the lung, usually in the cells lining air passages. The two main types are small cell lung cancer and non-small cell lung cancer. These types are diagnosed based on how the cells look under a microscope. Cell is the individual unit that makes up the tissues of the body. All living things are made up of one or more cells. Mutation, any change in the DNA sequence of a cell. Mutations may be caused by mistakes during cell division, or they may be caused by exposure to DNA-damaging agents in the environment. Mutations can be harmful, beneficial, or have no effect. If they occur in cells that make eggs or sperm, they can be inherited; if mutations occur in other types of cells, they are not inherited. Certain mutations may lead to cancer or other diseases.
- Finally, it`s possible to conclude that, doctor Charles Rudin , director, Lung Cancer Therapeutics Program at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins and a member of LUNGevity Foundation`s scientific advisory board said: Crizotinib is a prime example of successful deployment of a targeted inhibitor against a driver mutation in lung cancer. Like the EGFR inhibitors in EGFR-mutant lung cancer, crizotinib is remarkably effective against ALK-translocated lung cancer. He also pointed out the urgency of additional research, saying, As with the EGFR inhibitors, acquired resistance to this targeted inhibitor is already emerging as an important problem, and is a focus of ongoing research in the field. EGFR is the protein found on the surface of some cells and to which epidermal growth factor binds, causing the cells to divide. It is found at abnormally high levels on the surface of many types of cancer cells, so these cells may divide excessively in the presence of epidermal growth factor. Also called epidermal growth factor receptor, ErbB1, and HER1. Comprehensive cancer center is a cancer research center that gets support from the National Cancer Institute (NCI) to do cancer research and provide services directly to cancer patients. Scientists and doctors at these centers do basic laboratory research and clinical trials, and they study the patterns, causes, and control of cancer in groups of people. Also, they take part in multicenter clinical trials, which enroll patients from many parts of the country. Comprehensive Cancer Centers also give cancer information to health care professionals and the public. More information about the NCI Cancer Centers Program can be found on the NCI`s Web site at http://cancercenters.cancer.gov/.
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