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What is cancer human corticotropin-releasing factor?
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- cancer human corticotropin-releasing factor
Corticotropin is a hormone made in the pituitary gland. Corticotropin acts on the outer part of the adrenal gland to control its release of corticosteroid hormones. More corticotropin is made during times of stress. Also called ACTH and adrenocorticotropic hormone. Human corticotropin-releasing factor is a substance being studied in the treatment of brain cancer. It is made naturally by the hypothalamus (a part of the brain) and can also be made in the laboratory. Human corticotropin-releasing factor may help reduce symptoms caused by edema (swelling) of the brain. It is a type of neurohormone. Also called hCRF. Cancer is a term for diseases in which abnormal cells divide without control and can invade nearby tissues. Cancer cells can also spread to other parts of the body through the blood and lymph systems. There are several main types of cancer. Carcinoma is a cancer that begins in the skin or in tissues that line or cover internal organs. Sarcoma is a cancer that begins in bone, cartilage, fat, muscle, blood vessels, or other connective or supportive tissue. Leukemia is a cancer that starts in blood-forming tissue such as the bone marrow, and causes large numbers of abnormal blood cells to be produced and enter the blood. Lymphoma and multiple myeloma are cancers that begin in the cells of the immune system. Central nervous system cancers are cancers that begin in the tissues of the brain and spinal cord. Also called malignancy.
Preview- It`s possible to deduce that, cells were treated with CRF (Chronic Renal Failure) at time 0 and were compared to vehicle only-treated cells at for the same period. Results are presented as % of the distance that remained open at that particular time point (Figure (Figure3).3). Hence, at 12 hours 75.08 1.57% of the initial gap was still open in control, vehicle treated cells, while 56.93 1.17% of the gap was still open in CRF (Chronic Renal Failure)-treated cells.
- It has been found that, to determine the potential mechanism involved in CRF-induced motility and invasiveness we examined the effect of CRF on actin polymerization dynamics. Actin a major cytoskeletal component in eukaryotic cells occurs in two forms, the globular or G-actin, which polymerizes into the filamentous or F-actin. Filamentous actin is the major component of microfilaments, present in filipodia and lamellipodia, which are reported to facilitate cell migration [39].
- It`s possible to assume that, it has been previously reported that CRF has anti-proliferative effects on cancer cell lines such as Ishikawa endometrial carcinoma cells and in MCF7 stimulated by estrogens [5,23]. Herein we confirmed that CRF suppresses MCF7 cell proliferation (Figure (Figure2A)2A) and determined its effect on apoptosis by measuring the exposure of phosphatidyl-serine on the cell membrane. MCF7 were treated with CRF at a concentration of 10-8 M for 24, 48, and 72 hours and apoptosis was quantified. Endometrial, having to do with the endometrium (the layer of tissue that lines the uterus). Apoptosis is a type of cell death in which a series of molecular steps in a cell lead to its death. This is one method the body uses to get rid of unneeded or abnormal cells. The process of apoptosis may be blocked in cancer cells. Also called programmed cell death. Membrane is a very thin layer of tissue that covers a surface. Concentration is in science, the amount of a substance, such as a salt, that is in a certain amount of tissue or liquid, such as blood. A substance becomes more concentrated when less water is present. For example, the salt in urine may become more concentrated when a person doesn`t drink enough water. Cell proliferation is an increase in the number of cells as a result of cell growth and cell division. Carcinoma, cancer that begins in the skin or in tissues that line or cover internal organs.
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