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What is cancer homeostatic?
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- cancer homeostatic
Homeostatic, having to do with homeostasis, which is a state of balance among all the body systems, needed for the body to function correctly. Cancer is a term for diseases in which abnormal cells divide without control and can invade nearby tissues. Cancer cells can also spread to other parts of the body through the blood and lymph systems. There are several main types of cancer. Carcinoma is a cancer that begins in the skin or in tissues that line or cover internal organs. Sarcoma is a cancer that begins in bone, cartilage, fat, muscle, blood vessels, or other connective or supportive tissue. Leukemia is a cancer that starts in blood-forming tissue such as the bone marrow, and causes large numbers of abnormal blood cells to be produced and enter the blood. Lymphoma and multiple myeloma are cancers that begin in the cells of the immune system. Central nervous system cancers are cancers that begin in the tissues of the brain and spinal cord. Also called malignancy.
Preview- One can determine, we show that stringently FACS (Fellow, American College of Surgeons)-separated subsets of G-2 cells are competent to reconstitute the initial cellular composition of the cell culture when individually cultured. Our data argue for a self-reproducing homeostatic cancer cell system, where the balance relies on interconversion of the complementary cellular subsets, their interactions and transcriptional competence. In support of the EMT (Emergency Medical Technician)-CSC model [9], we identified in the G-2 culture a self-renewing population of cells characterized by expression of Thy1 and displaying spontaneous reversibility of a quasi-mesenchymal differentiation state. Cell culture is the growth of microorganisms such as bacteria and yeast, or human, plant, or animal cells in the laboratory. Cell cultures may be used to diagnose infections, to test new drugs, and in research. Differentiation is in biology, describes the processes by which immature cells become mature cells with specific functions. In cancer, this describes how much or how little tumor tissue looks like the normal tissue it came from. Well-differentiated cancer cells look more like normal cells and tend to grow and spread more slowly than poorly differentiated or undifferentiated cancer cells. Differentiation is used in tumor grading systems, which are different for each type of cancer. Mesenchymal, refers to cells that develop into connective tissue, blood vessels, and lymphatic tissue. Culture is the beliefs, values, and behaviors that are shared within a group, such as a religious group or a nation. Culture includes language, customs, and beliefs about roles and relationships.
- As an alternative, it has been suggested that phenotypic plasticity is a basic property of the stem cell state [47]. Extending the meaning of plasticity, it has been questioned that normal and cancer stem cells exist as an entity defined by discrete molecular properties, but rather together with the population of committed progenitors and their differentiated progeny comprise a homeostatic stem cell system where the cellular composition is regulated by feed-back mechanisms [10]. Our and other studies [48][50] suggest that, at least in established clonal cell cultures, but most likely also in tumor tissue, heterogeneity of differentiation states is an intrinsic property of what we term the cancer cell system (CCS (Canadian Cardiovascular Society)) (Figure 14). Progeny, offspring; the product of reproduction or replication. Tissue is a group or layer of cells that work together to perform a specific function. Tumor is an abnormal mass of tissue that results when cells divide more than they should or do not die when they should. Tumors may be benign (not cancer), or malignant (cancer). Also called neoplasm. Stem cell is a cell from which other types of cells develop. For example, blood cells develop from blood-forming stem cells.
- It`s been discovered that, british Journal of Cancer - Targeting homeostatic mechanisms of endoplasmic reticulum stress to increase susceptibility of cancer cells to fenretinide-induced apoptosis the role of stress proteins ERdj5 and ERp57. Fenretinide is a substance being studied in the treatment and prevention of some types of cancer. Fenretinide may cause ceramide (a wax-like substance) to build up in tumor cells and kill them. It is a type of retinoid, which are substances related to vitamin A. Apoptosis is a type of cell death in which a series of molecular steps in a cell lead to its death. This is one method the body uses to get rid of unneeded or abnormal cells. The process of apoptosis may be blocked in cancer cells. Also called programmed cell death. Stress is the response of the body to physical, mental, or emotional pressure. This may make a person feel frustrated, angry, or anxious, and may cause unhealthy chemical changes in the body. Untreated, long-term stress may lead to many types of mental and physical health problems.
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