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What is cancer nilutamide?
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- cancer nilutamide
Nilutamide is a drug that blocks the effects of male hormones in the body. It is a type of antiandrogen. Cancer is a term for diseases in which abnormal cells divide without control and can invade nearby tissues. Cancer cells can also spread to other parts of the body through the blood and lymph systems. There are several main types of cancer. Carcinoma is a cancer that begins in the skin or in tissues that line or cover internal organs. Sarcoma is a cancer that begins in bone, cartilage, fat, muscle, blood vessels, or other connective or supportive tissue. Leukemia is a cancer that starts in blood-forming tissue such as the bone marrow, and causes large numbers of abnormal blood cells to be produced and enter the blood. Lymphoma and multiple myeloma are cancers that begin in the cells of the immune system. Central nervous system cancers are cancers that begin in the tissues of the brain and spinal cord. Also called malignancy.
Preview- It is obvious that, men with histologically confirmed prostate cancer not amenable to curative surgery or radiation therapy were eligible for the study if they had radiographic or PSA progression on at least one antiandrogen (not nilutamide) despite continued androgen suppression and standard antiandrogen withdrawal periods. All men received nilutamide 150mg/day orally for ? Curative surgery is an operation to remove cancerous tissue. Part or all of the organ or tissue in which the cancer started and a small amount of healthy tissue around the cancer is removed. Nearby lymph nodes may also be removed. Curative surgery may be used as primary therapy for localized cancer and is often followed by chemotherapy or radiation therapy to kill any cancer cells that remain. Radiation, energy released in the form of particle or electromagnetic waves. Common sources of radiation include radon gas, cosmic rays from outer space, medical x-rays, and energy given off by a radioisotope (unstable form of a chemical element that releases radiation as it breaks down and becomes more stable). Progression is in medicine, the course of a disease, such as cancer, as it becomes worse or spreads in the body. PSA is a protein made by the prostate gland and found in the blood. PSA blood levels may be higher than normal in men who have prostate cancer, benign prostatic hyperplasia (BPH), or infection or inflammation of the prostate gland. Also called prostate-specific antigen. Surgery is a procedure to remove or repair a part of the body or to find out whether disease is present. An operation. Androgen suppression, treatment to suppress or block the production or action of male hormones. This is done by having the testicles removed, by taking female sex hormones, or by taking drugs called antiandrogens. Also called androgen ablation and androgen deprivation. Antiandrogen is a substance that prevents cells from making or using androgens (hormones that play a role in the formation of male sex characteristics). Antiandrogens may stop some cancer cells from growing. Some antiandrogens are used to treat prostate cancer, and others are being studied for this use. An antiandrogen is a type of hormone antagonist. Prostate is a gland in the male reproductive system. The prostate surrounds the part of the urethra (the tube that empties the bladder) just below the bladder, and produces a fluid that forms part of the semen. Prostate cancer, cancer that forms in tissues of the prostate (a gland in the male reproductive system found below the bladder and in front of the rectum). Prostate cancer usually occurs in older men. Radiation therapy is the use of high-energy radiation from x-rays, gamma rays, neutrons, protons, and other sources to kill cancer cells and shrink tumors. Radiation may come from a machine outside the body (external-beam radiation therapy), or it may come from radioactive material placed in the body near cancer cells (internal radiation therapy). Systemic radiation therapy uses a radioactive substance, such as a radiolabeled monoclonal antibody, that travels in the blood to tissues throughout the body. Also called irradiation and radiotherapy. Therapy, treatment.
- It`s that, keywords: antiandrogen; prostate cancer; nilutamide; bicalutamide; response OBJECTIVE To determine the prostate-specific antigen (PSA) response and time to PSA or radiographic progression in men with prostate cancer refractory to bicalutamide and/or flutamide therapy. PATIENTS AND (Academy of Nutrition and Dietetics (formerly American Dietetic Association (ADA))) METHODS Men with histologically confirmed prostate cancer not amenable to curative surgery or radiation therapy were eligible for the study if they had radiographic or PSA progression on at least one antiandrogen (not nilutamide) despite continued androgen suppression and standard antiandrogen withdrawal periods. Prostate-specific antigen is a protein made by the prostate gland and found in the blood. Prostate-specific antigen blood levels may be higher than normal in men who have prostate cancer, benign prostatic hyperplasia (BPH), or infection or inflammation of the prostate gland. Also called PSA. Response is in medicine, an improvement related to treatment. Flutamide is an anticancer drug that is a type of antiandrogen. Refractory is in medicine, describes a disease or condition that does not respond to treatment. Bicalutamide is an anticancer drug that belongs to the family of drugs called antiandrogens. Antigen, any substance that causes the body to make a specific immune response.
- You can determine, therefore, it seems reasonable to deprive advanced prostate cancers of most of their supply of male hormones by castration, and to use antiandrogens to block the effect of the small amounts that continue to be made available by the adrenal glands. To evaluate the effectiveness of this approach, 203 patients with advanced prostate cancer were treated surgically and randomly assigned to receive either placebo or nilutamide, a nonsteroidal antiandrogen. The patients treated with castration and nilutamide achieved a greater proportion of successful responses to therapy, 46 versus 20 percent. Castration, removal or destruction of the testicles or ovaries using radiation, surgery, or drugs. Medical castration refers to the use of drugs to suppress the function of the ovaries or testicles. Placebo is an inactive substance or treatment that looks the same as, and is given the same way as, an active drug or treatment being tested. The effects of the active drug or treatment are compared to the effects of the placebo.
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