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Lung, one of a pair of organs in the chest that supplies the body with oxygen, and removes carbon dioxide from the body. Lung cancer, cancer that forms in tissues of the lung, usually in the cells lining air passages. The two main types are small cell lung cancer and non-small cell lung cancer. These types are diagnosed based on how the cells look under a microscope. Cancer is a term for diseases in which abnormal cells divide without control and can invade nearby tissues. Cancer cells can also spread to other parts of the body through the blood and lymph systems. There are several main types of cancer. Carcinoma is a cancer that begins in the skin or in tissues that line or cover internal organs. Sarcoma is a cancer that begins in bone, cartilage, fat, muscle, blood vessels, or other connective or supportive tissue. Leukemia is a cancer that starts in blood-forming tissue such as the bone marrow, and causes large numbers of abnormal blood cells to be produced and enter the blood. Lymphoma and multiple myeloma are cancers that begin in the cells of the immune system. Central nervous system cancers are cancers that begin in the tissues of the brain and spinal cord. Also called malignancy.
Preview- It is obvious that, biothera announced today that its second Phase II non-small cell lung cancer trial, evaluating Imprime PGG in combination with bevacizumab (Avastin) and two chemotherapeutic agents, has achieved its stage 1 endpoint and has begun enrolling patients for stage 2 of the study. Stage is the extent of a cancer in the body. Staging is usually based on the size of the tumor, whether lymph nodes contain cancer, and whether the cancer has spread from the original site to other parts of the body. Non-small cell lung cancer is a group of lung cancers that are named for the kinds of cells found in the cancer and how the cells look under a microscope. The three main types of non-small cell lung cancer are squamous cell carcinoma, large cell carcinoma, and adenocarcinoma. Non-small cell lung cancer is the most common kind of lung cancer. Cell is the individual unit that makes up the tissues of the body. All living things are made up of one or more cells. Small cell lung cancer is an aggressive (fast-growing) cancer that forms in tissues of the lung and can spread to other parts of the body. The cancer cells look small and oval-shaped when looked at under a microscope. Avastin is a drug used to treat glioblastoma (a type of brain cancer) and certain types of colorectal cancer, lung cancer, and kidney cancer. It is also being studied in the treatment of other types of cancer. Avastin binds to a protein called vascular endothelial growth factor (VEGF). This may prevent the growth of new blood vessels that tumors need to grow. It is a type of antiangiogenesis agent and a type of monoclonal antibody. Also called bevacizumab. Endpoint is in clinical trials, an event or outcome that can be measured objectively to determine whether the intervention being studied is beneficial. The endpoints of a clinical trial are usually included in the study objectives. Some examples of endpoints are survival, improvements in quality of life, relief of symptoms, and disappearance of the tumor. Bevacizumab is a drug used to treat glioblastoma (a type of brain cancer) and certain types of colorectal cancer, lung cancer, and kidney cancer. It is also being studied in the treatment of other types of cancer. Bevacizumab binds to a protein called vascular endothelial growth factor (VEGF). This may prevent the growth of new blood vessels that tumors need to grow. It is a type of antiangiogenesis agent and a type of monoclonal antibody. Also called Avastin.
- It would appear apparant that, the initial results of both our non-small lung cancer trials are very promising and further demonstrate Imprime PGGs unique mechanism of action and synergy with monoclonal antibody therapies, said Dan Conners, president of Biotheras Pharmaceutical Group. Antibody is a protein made by plasma cells (a type of white blood cell) in response to an antigen (a substance that causes the body to make a specific immune response). Each antibody can bind to only one specific antigen. The purpose of this binding is to help destroy the antigen. Some antibodies destroy antigens directly. Others make it easier for white blood cells to destroy the antigen. An antibody is a type of immunoglobulin. Monoclonal antibody is a type of protein made in the laboratory that can bind to substances in the body, including tumor cells. There are many kinds of monoclonal antibodies. Each monoclonal antibody is made to find one substance. Monoclonal antibodies are being used to treat some types of cancer and are being studied in the treatment of other types. They can be used alone or to carry drugs, toxins, or radioactive materials directly to a tumor.
- It has been discovered that, the Anglo-Swedish drugmaker said Recentin had shown some evidence of clinical activity in lung cancer but a phase II/III trial would not progress into phase III because among patients given the drug there appeared to be an imbalance in toxicity. Recentin is a substance being studied in the treatment of some types of cancer. Recentin may prevent the growth of new blood vessels that tumors need to grow and may kill cancer cells. It is a type of antiangiogenesis agent and a type of vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitor. Also called AZD2171 and cediranib maleate. Toxicity is the extent to which something is poisonous or harmful. Clinical, having to do with the examination and treatment of patients. Phase II/III trial is a trial to study response to a new treatment and the effectiveness of the treatment compared with the standard treatment regimen.
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