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What is cancer belinostat?
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- cancer belinostat
Cancer is a term for diseases in which abnormal cells divide without control and can invade nearby tissues. Cancer cells can also spread to other parts of the body through the blood and lymph systems. There are several main types of cancer. Carcinoma is a cancer that begins in the skin or in tissues that line or cover internal organs. Sarcoma is a cancer that begins in bone, cartilage, fat, muscle, blood vessels, or other connective or supportive tissue. Leukemia is a cancer that starts in blood-forming tissue such as the bone marrow, and causes large numbers of abnormal blood cells to be produced and enter the blood. Lymphoma and multiple myeloma are cancers that begin in the cells of the immune system. Central nervous system cancers are cancers that begin in the tissues of the brain and spinal cord. Also called malignancy. Belinostat is a substance being studied in the treatment of cancer. Belinostat blocks enzymes needed for cell division and may kill cancer cells. It also prevents the growth of blood vessels needed for tumors to grow and may make tumor cells more sensitive to other anticancer drugs. It is a type of histone deacetylase (HDAC) inhibitor, a type of angiogenesis inhibitor, and a type of chemosensitizer. Also called PXD101.
Preview- One can deduce that, ha-ras transgenic mice with established superficial bladder cancer were randomized to receive either belinostat dissolved in L-Arginine (100 mg/kg, IP, qd, 5 days on, 2 days off, 3 cycles) or L-Arginine alone as a control following the same dose scheduling. Bladder cancer, cancer that forms in tissues of the bladder (the organ that stores urine). Most bladder cancers are transitional cell carcinomas (cancer that begins in cells that normally make up the inner lining of the bladder). Other types include squamous cell carcinoma (cancer that begins in thin, flat cells) and adenocarcinoma (cancer that begins in cells that make and release mucus and other fluids). The cells that form squamous cell carcinoma and adenocarcinoma develop in the inner lining of the bladder as a result of chronic irritation and inflammation. Arginine, one of the twenty common amino acids (building blocks of proteins). Arginine is being studied as a nutritional supplement in the treatment and prevention of cancer and other conditions. Also called L-arginine. Bladder is the organ that stores urine. IP, within the peritoneal cavity (the area that contains the abdominal organs). Also called intraperitoneal. Transgenic mice, mice that have had DNA from another source put into their DNA. The foreign DNA is put into the nucleus of a fertilized mouse egg. The new DNA becomes part of every cell and tissue of the mouse. These mice are used in the laboratory to study diseases. L-arginine, one of the twenty common amino acids (building blocks of proteins). L-arginine is being studied as a nutritional supplement in the treatment and prevention of cancer and other conditions. Also called arginine. Superficial, affecting cells on the surface. Not invasive.
- Apparently, growth inhibition and cell cycle distribution effect of belinostat on 5637, T24, J82, and RT4 urothelial lines were assessed. Ha-ras transgenic mice with established superficial bladder cancer were randomized to receive either belinostat or vehicle alone, and assessed for bladder weight, hematuria, gene expression profiling, and immunohistochemistry (IHC). Immunohistochemistry is a technique used to identify specific molecules in different kinds of tissue. The tissue is treated with antibodies that bind the specific molecule. These are made visible under a microscope by using a color reaction, a radioisotope, colloidal gold, or a fluorescent dye. Immunohistochemistry is used to help diagnose diseases, such as cancer, and to detect the presence of microorganisms. It is also used in basic research to understand how cells grow and differentiate (become more specialized). Gene is the functional and physical unit of heredity passed from parent to offspring. Genes are pieces of DNA, and most genes contain the information for making a specific protein. Cell is the individual unit that makes up the tissues of the body. All living things are made up of one or more cells. Cell cycle is the process a cell goes through each time it divides. The cell cycle consists of a series of steps during which the chromosomes and other cell material double to make two copies. The cell then divides into two daughter cells, each receiving one copy of the doubled material. The cell cycle is complete when each daughter cell is surrounded by its own outer membrane. Also called mitotic cycle. Hematuria, blood in the urine. Gene expression is the process by which a gene gets turned on in a cell to make RNA and proteins. Gene expression may be measured by looking at the RNA, or the protein made from the RNA, or what the protein does in a cell.
- One can deduce that, figure 1 Inhibition of bladder cancer cell proliferation by belinostat at 1, 2 and 5 M for 48 h in the human urinary bladder cancer cell lines 5637, T24, J82 and RT4. Urinary, having to do with urine or the organs of the body that produce and get rid of urine. Cell proliferation is an increase in the number of cells as a result of cell growth and cell division.
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