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What is cancer colon crypt?
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- cancer colon crypt
Colon is the longest part of the large intestine, which is a tube-like organ connected to the small intestine at one end and the anus at the other. The colon removes water and some nutrients and electrolytes from partially digested food. The remaining material, solid waste called stool, moves through the colon to the rectum and leaves the body through the anus. Colon crypt, tube-like gland found in the lining of the colon and rectum. Colon crypt cells renew the lining of the intestine and make mucus. Also called gland of Lieberkuhn. Cancer is a term for diseases in which abnormal cells divide without control and can invade nearby tissues. Cancer cells can also spread to other parts of the body through the blood and lymph systems. There are several main types of cancer. Carcinoma is a cancer that begins in the skin or in tissues that line or cover internal organs. Sarcoma is a cancer that begins in bone, cartilage, fat, muscle, blood vessels, or other connective or supportive tissue. Leukemia is a cancer that starts in blood-forming tissue such as the bone marrow, and causes large numbers of abnormal blood cells to be produced and enter the blood. Lymphoma and multiple myeloma are cancers that begin in the cells of the immune system. Central nervous system cancers are cancers that begin in the tissues of the brain and spinal cord. Also called malignancy.
Preview- One can deduce that, the majority of colorectal cancers originate in a multi-step process from adenomatous polyps, acquiring a series of somatic mutations (i.e., p53, KRas, and APCs) (14). Colorectal cancer is believed to arise from colonic stem or progenitor cells in association with nuclear localization of -catenin leading to crypt fission, the development of aberrant crypt foci (ACFs), and the emergence of colorectal cancer stem cells. Hyperproliferation of the colonic epithelium has been recognized as a risk factor for colorectal cancer development and represents an important first step in a sequence of events leading to neoplastic progression (5). Localization is the process of determining or marking the location or site of a lesion or disease. May also refer to the process of keeping a lesion or disease in a specific location or site. Progression is in medicine, the course of a disease, such as cancer, as it becomes worse or spreads in the body. Somatic, having to do with the body. Colorectal, having to do with the colon or the rectum. Epithelium is a thin layer of tissue that covers organs, glands, and other structures within the body. Aberrant crypt foci, clusters of abnormal tube-like glands in the lining of the colon and rectum. Aberrant crypt foci form before colorectal polyps and are one of the earliest changes that can be seen in the colon that may lead to cancer. Also called ACF. Risk factor, something that increases the chance of developing a disease. Some examples of risk factors for cancer are age, a family history of certain cancers, use of tobacco products, being exposed to radiation or certain chemicals, infection with certain viruses or bacteria, and certain genetic changes.
- You can recognize, hyperproliferation of the colonic epithelium, leading to expansion of colonic crypt progenitors, is a recognized risk factor for colorectal cancer. Overexpression of progastrin, a nonamidated and incompletely processed product of the gastrin gene, has been shown to induce colonic hyperproliferation and promote colorectal cancer in mice, but the mechanism of pathogenesis has not been defined. Gene is the functional and physical unit of heredity passed from parent to offspring. Genes are pieces of DNA, and most genes contain the information for making a specific protein.
- It`s apparent that, research Article Inactivating cholecystokinin-2 receptor inhibits progastrin-dependent colonic crypt fission, proliferation, and colorectal cancer in mice Guangchun Jin1, Vigneshwaran Ramanathan1, Michael Quante1, Gwang Ho Baik1, Xiangdong Yang1, Sophie S.W. Receptor is a molecule inside or on the surface of a cell that binds to a specific substance and causes a specific effect in the cell.
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