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What is cancer autoantibody?
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- cancer autoantibody
Autoantibody is an antibody made against substances formed by a person`s own body. Autoantibodies can directly destroy cells that have the substances on them or can make it easier for other white blood cells to destroy them. Some autoimmune diseases are caused by autoantibodies. Cancer is a term for diseases in which abnormal cells divide without control and can invade nearby tissues. Cancer cells can also spread to other parts of the body through the blood and lymph systems. There are several main types of cancer. Carcinoma is a cancer that begins in the skin or in tissues that line or cover internal organs. Sarcoma is a cancer that begins in bone, cartilage, fat, muscle, blood vessels, or other connective or supportive tissue. Leukemia is a cancer that starts in blood-forming tissue such as the bone marrow, and causes large numbers of abnormal blood cells to be produced and enter the blood. Lymphoma and multiple myeloma are cancers that begin in the cells of the immune system. Central nervous system cancers are cancers that begin in the tissues of the brain and spinal cord. Also called malignancy.
Preview- It might seem apparant that, plasma from normal controls (n = 50), patients with non-small cell lung cancer (n = 82) and patients with small cell lung cancer (n = 22) were investigated for the presence of autoantibodies to p53, c-myc, HER2, NY-ESO-1, CAGE, MUC1 and GBU4-5 by enzyme-linked immunosorbent assay. Lung cancer, cancer that forms in tissues of the lung, usually in the cells lining air passages. The two main types are small cell lung cancer and non-small cell lung cancer. These types are diagnosed based on how the cells look under a microscope. Enzyme is a protein that speeds up chemical reactions in the body. Assay is a laboratory test to find and measure the amount of a specific substance. Cell is the individual unit that makes up the tissues of the body. All living things are made up of one or more cells. Enzyme-linked immunosorbent assay is a laboratory technique that uses antibodies linked to enzymes to detect and measure the amount of a substance in a solution, such as serum. The test is done using a solid surface to which the antibodies and other molecules stick. In the final step, an enzyme reaction takes place that causes a color change that can be read using a special machine. There are many different ways that an enzyme-linked immunosorbent assay can be done. Enzyme-linked immunosorbent assays may be used to help diagnose certain diseases. Also called ELISA. Plasma is the clear, yellowish, fluid part of the blood that carries the blood cells. The proteins that form blood clots are in plasma. Non-small cell lung cancer is a group of lung cancers that are named for the kinds of cells found in the cancer and how the cells look under a microscope. The three main types of non-small cell lung cancer are squamous cell carcinoma, large cell carcinoma, and adenocarcinoma. Non-small cell lung cancer is the most common kind of lung cancer. Small cell lung cancer is an aggressive (fast-growing) cancer that forms in tissues of the lung and can spread to other parts of the body. The cancer cells look small and oval-shaped when looked at under a microscope. Lung, one of a pair of organs in the chest that supplies the body with oxygen, and removes carbon dioxide from the body.
- One can presume that, moreover, autoantibodies can be present in different types of cancer and thus lack specificity. To achieve the highest degree of sensitivity and specificity and to encompass the histological heterogeneity of lung cancer, combining multiple autoantibody reactivities into a panel assay test has been proposed as relevant screening tests and validated in several independent populations of patients including healthy controls, noncancer chronically diseased patients, and patients with cancer (Table 2). Hanash and coworkers89 proposed for the first time a panel of autoantibodies for early detection of lung cancer. Sensitivity, when referring to a medical test, sensitivity refers to the percentage of people who test positive for a specific disease among a group of people who have the disease. No test has 100% sensitivity because some people who have the disease will test negative for it (false negatives). Specificity, when referring to a medical test, specificity refers to the percentage of people who test negative for a specific disease among a group of people who do not have the disease. No test is 100% specific because some people who do not have the disease will test positive for it (false positive). Screening, checking for disease when there are no symptoms. Since screening may find diseases at an early stage, there may be a better chance of curing the disease. Examples of cancer screening tests are the mammogram (breast), colonoscopy (colon), and the Pap test and HPV test (cervix). Screening can also include checking for a person`s risk of developing an inherited disease by doing a genetic test.
- One can view, lung cancer; Autoantibody; Immune response; Screening Response is in medicine, an improvement related to treatment. Immune response is the activity of the immune system against foreign substances (antigens).
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