What is cancer intercellular communication?

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What is cancer intercellular communication?

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1. cancer intercellular communication

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• Now we show that in cancer cells intercellular communication via gap junctions propagates cell death and thereby contributes to the tumor suppression mediated by Connexins, particularly when their direct inhibitory effect on cell proliferation is not evident


• The hypothesis that " cancer was the result of dysfunctional gap junctional intercellular communication", which was postulated by Loewenstein (22), has been modified to integrate some of the aforementioned ideas (40,41)


• namely that reversible disruption of gap junctional intercellular communication plays a role during the tumor promotion phase of carcinogenesis and that stable down-regulation of GJIC leads to the conversion of a premalignant cell to an invasive and metastatic cancer cell, a brief review of the major theories of carcinogenesis will be undertaken

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