ctSearch Results
Original Query
What is cancer Peutz-Jeghers syndrome?
Search Results
- cancer peutz-jeghers syndrome
Peutz-Jeghers syndrome is a genetic disorder in which polyps form in the intestine and dark spots appear on the mouth and fingers. Having PJS increases the risk of developing gastrointestinal and many other types of cancer. Also called PJS. Syndrome is a set of symptoms or conditions that occur together and suggest the presence of a certain disease or an increased chance of developing the disease. Cancer is a term for diseases in which abnormal cells divide without control and can invade nearby tissues. Cancer cells can also spread to other parts of the body through the blood and lymph systems. There are several main types of cancer. Carcinoma is a cancer that begins in the skin or in tissues that line or cover internal organs. Sarcoma is a cancer that begins in bone, cartilage, fat, muscle, blood vessels, or other connective or supportive tissue. Leukemia is a cancer that starts in blood-forming tissue such as the bone marrow, and causes large numbers of abnormal blood cells to be produced and enter the blood. Lymphoma and multiple myeloma are cancers that begin in the cells of the immune system. Central nervous system cancers are cancers that begin in the tissues of the brain and spinal cord. Also called malignancy.
Preview- You can notice, mutation detection rates of 10-94% have been achieved at different centers, depending on the screening method, with considerable uncharacterized genetic heterogeneity remaining in this syndrome [2,7]. Most mutations are frameshift or nonsense changes, which result in an abnormal truncated protein and the consequent loss of kinase activity [8]. Mutation, any change in the DNA sequence of a cell. Mutations may be caused by mistakes during cell division, or they may be caused by exposure to DNA-damaging agents in the environment. Mutations can be harmful, beneficial, or have no effect. If they occur in cells that make eggs or sperm, they can be inherited; if mutations occur in other types of cells, they are not inherited. Certain mutations may lead to cancer or other diseases. Kinase is a type of enzyme (a protein that speeds up chemical reactions in the body) that adds chemicals called phosphates to other molecules, such as sugars or proteins. This may cause other molecules in the cell to become either active or inactive. Kinases are a part of many cell processes. Some cancer treatments target certain kinases that are linked to cancer. Protein is a molecule made up of amino acids. Proteins are needed for the body to function properly. They are the basis of body structures, such as skin and hair, and of other substances such as enzymes, cytokines, and antibodies. Abnormal, not normal. Describes a state, condition, or behavior that is unusual or different from what is considered normal. An abnormal lesion or growth in or on the body may be benign (not cancer), precancerous or premalignant (likely to become cancer), or malignant (cancer). Screening, checking for disease when there are no symptoms. Since screening may find diseases at an early stage, there may be a better chance of curing the disease. Examples of cancer screening tests are the mammogram (breast), colonoscopy (colon), and the Pap test and HPV test (cervix). Screening can also include checking for a person`s risk of developing an inherited disease by doing a genetic test. Genetic, inherited; having to do with information that is passed from parents to offspring through genes in sperm and egg cells.
- It`s been discovered that, PJS Peutz-Jeghers syndrome; STK11 Serine threonine kinase 11; GI gastrointestinal. Gastrointestinal, refers to the stomach and intestines. Also called GI.
NEW: Try our Cancer Expert Fact Search, and get direct access to our Knowledge Base (KB).
Disclaimer: On occasion, search results will contain fragmented, and erroneous (misspelled, incorrect grammar and malformatted) text. It is not possible, for our Bots to automatically correct these, afterall they represent the corpus created by individuals and/or other Bots and who have placed it on the Internet. Keep in mind, Cancer Expert Search is a search engine, and we are required to return search results as closely resembling their original format, when they were discovered by our Bots (including all errors).
