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What is cancer SCH 66336?
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- cancer sch 66336
Cancer is a term for diseases in which abnormal cells divide without control and can invade nearby tissues. Cancer cells can also spread to other parts of the body through the blood and lymph systems. There are several main types of cancer. Carcinoma is a cancer that begins in the skin or in tissues that line or cover internal organs. Sarcoma is a cancer that begins in bone, cartilage, fat, muscle, blood vessels, or other connective or supportive tissue. Leukemia is a cancer that starts in blood-forming tissue such as the bone marrow, and causes large numbers of abnormal blood cells to be produced and enter the blood. Lymphoma and multiple myeloma are cancers that begin in the cells of the immune system. Central nervous system cancers are cancers that begin in the tissues of the brain and spinal cord. Also called malignancy. SCH 66336 is an anticancer drug that belongs to the family of drugs called enzyme inhibitors. Also called lonafarnib.
Preview- It might seem to be apparant that, PURPOSE Randomized phase I trial to compare the effectiveness of different doses of SCH (Sole Community Hospitals) 66336 before surgery in treating patients who have colorectal cancer that has metastasized to the liver. Colorectal, having to do with the colon or the rectum. Colorectal cancer, cancer that develops in the colon (the longest part of the large intestine) and/or the rectum (the last several inches of the large intestine before the anus). Surgery is a procedure to remove or repair a part of the body or to find out whether disease is present. An operation. Phase I trial is the first step in testing a new treatment in humans. These studies test the best way to give a new treatment (for example, by mouth, intravenous infusion, or injection) and the best dose. The dose is usually increased a little at a time in order to find the highest dose that does not cause harmful side effects. Because little is known about the possible risks and benefits of the treatments being tested, phase I trials usually include only a small number of patients who have not been helped by other treatments. Liver is a large organ located in the upper abdomen. The liver cleanses the blood and aids in digestion by secreting bile.
- One can deduce that, a phase II trial of farnesyl protein transferase inhibitor SCH 66336, given by twice-daily oral administration, in patients with metastatic colorectal cancer refractory to 5-fluorouracil and irinotecan. Phase II trial is a study to test whether a new treatment has an anticancer effect (for example, whether it shrinks a tumor or improves blood test results) and whether it works against a certain type of cancer. Refractory is in medicine, describes a disease or condition that does not respond to treatment. Metastatic, having to do with metastasis, which is the spread of cancer from the primary site (place where it started) to other places in the body. Irinotecan is the active ingredient in a drug used alone or with other drugs to treat colon cancer or rectal cancer that has spread to other parts of the body or has come back after treatment with fluorouracil. It is also being studied in the treatment of other types of cancer. Irinotecan blocks certain enzymes needed for cell division and DNA repair, and it may kill cancer cells. It is a type of topoisomerase inhibitor and a type of camptothecin analog. Oral, by or having to do with the mouth. Protein is a molecule made up of amino acids. Proteins are needed for the body to function properly. They are the basis of body structures, such as skin and hair, and of other substances such as enzymes, cytokines, and antibodies. 5-fluorouracil is a drug used to treat cancers of the breast, stomach, and pancreas, and certain types of colorectal and head and neck cancers. It is also used in a cream to treat basal cell skin cancer and actinic keratosis (a skin condition that may become cancer). It is being studied in the treatment of other conditions and types of cancer. 5-fluorouracil stops cells from making DNA and it may kill cancer cells. It is a type of antimetabolite. Also called 5-FU, Adrucil, Efudex, Fluoroplex, and fluorouracil. Fluorouracil is a drug used to treat cancers of the breast, stomach, and pancreas, and certain types of colorectal and head and neck cancers. It is also used in a cream to treat basal cell skin cancer and actinic keratosis (a skin condition that may become cancer). It is being studied in the treatment of other conditions and types of cancer. Fluorouracil stops cells from making DNA and it may kill cancer cells. It is a type of antimetabolite. Also called 5-fluorouracil, 5-FU, Adrucil, Efudex, and Fluoroplex. Administration is in medicine, the act of giving a treatment, such as a drug, to a patient. It can also refer to the way it is given, the dose, or how often it is given.
- It appears that, PATIENTS AND (Academy of Nutrition and Dietetics (formerly American Dietetic Association (ADA))) METHODS We report the results of a phase II trial of SCH 66336, an FPTase inhibitor, in patients with metastatic colorectal cancer.
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