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Cancer - What is CMV-specific immunohistochemical staining biopsy specimens
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- cancer cmv-specific immunohistochemical staining biopsy specimens
Biopsy is the removal of cells or tissues for examination by a pathologist. The pathologist may study the tissue under a microscope or perform other tests on the cells or tissue. There are many different types of biopsy procedures. The most common types include: (1) incisional biopsy, in which only a sample of tissue is removed; (2) excisional biopsy, in which an entire lump or suspicious area is removed; and (3) needle biopsy, in which a sample of tissue or fluid is removed with a needle. When a wide needle is used, the procedure is called a core biopsy. When a thin needle is used, the procedure is called a fine-needle aspiration biopsy. CMV is a virus that may be carried in an inactive state for life by healthy individuals. It is a cause of severe pneumonia in people with a suppressed immune system, such as those undergoing bone marrow transplantation or those with leukemia or lymphoma. Also called cytomegalovirus. Cancer is a term for diseases in which abnormal cells divide without control and can invade nearby tissues. Cancer cells can also spread to other parts of the body through the blood and lymph systems. There are several main types of cancer. Carcinoma is a cancer that begins in the skin or in tissues that line or cover internal organs. Sarcoma is a cancer that begins in bone, cartilage, fat, muscle, blood vessels, or other connective or supportive tissue. Leukemia is a cancer that starts in blood-forming tissue such as the bone marrow, and causes large numbers of abnormal blood cells to be produced and enter the blood. Lymphoma and multiple myeloma are cancers that begin in the cells of the immune system. Central nervous system cancers are cancers that begin in the tissues of the brain and spinal cord. Also called malignancy. Biopsy specimen, tissue removed from the body and examined under a microscope to determine whether disease is present.
Preview- One can view, in the nonamplified group, core-needle biopsies with 2 immunohistochemistry had no appreciable HER2 immunohistochemistry heterogeneity in the resection specimens that would have altered the patient treatment, which is confirmed by our cases showing no strong 3 staining. Heterogeneous staining is observed in both the groups, predominantly in the nonamplified group. Immunohistochemistry is a technique used to identify specific molecules in different kinds of tissue. The tissue is treated with antibodies that bind the specific molecule. These are made visible under a microscope by using a color reaction, a radioisotope, colloidal gold, or a fluorescent dye. Immunohistochemistry is used to help diagnose diseases, such as cancer, and to detect the presence of microorganisms. It is also used in basic research to understand how cells grow and differentiate (become more specialized). Resection, surgery to remove tissue or part or all of an organ. Heterogeneous, made up of elements or ingredients that are not alike.
- It could seem apparant that, to summarize, the core-needle biopsies sample is an excellent specimen for both immunohistochemistry and FISH testing. Amplification of HER2 in core-needle biopsies is associated with a substantial probability of finding strong staining in resection specimens, while no HER2 amplification of equivocal immunohistochemistry on core-needle biopsies is associated with 3 HER2 immunostaining on resection specimens. FISH is a laboratory technique used to look at genes or chromosomes in cells and tissues. Pieces of DNA that contain a fluorescent dye are made in the laboratory and added to cells or tissues on a glass slide. When these pieces of DNA bind to specific genes or areas of chromosomes on the slide, they light up when viewed under a microscope with a special light. Also called fluorescence in situ hybridization.
- Evidently, modern Pathology - Clinical importance of HER2 immunohistologic heterogeneous expression in core-needle biopsies vs resection specimens for equivocal (immunohistochemical score 2 ) cases Clinical, having to do with the examination and treatment of patients.
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