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What is cancer conditioning regimen?
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- cancer conditioning regimen
Conditioning regimen is the treatments used to prepare a patient for stem cell transplantation (a procedure in which a person receives blood stem cells, which make any type of blood cell). A conditioning regimen may include chemotherapy, monoclonal antibody therapy, and radiation to the entire body. It helps make room in the patient`s bone marrow for new blood stem cells to grow, helps prevent the patient`s body from rejecting the transplanted cells, and helps kill any cancer cells that are in the body. Regimen is a treatment plan that specifies the dosage, the schedule, and the duration of treatment. Cancer is a term for diseases in which abnormal cells divide without control and can invade nearby tissues. Cancer cells can also spread to other parts of the body through the blood and lymph systems. There are several main types of cancer. Carcinoma is a cancer that begins in the skin or in tissues that line or cover internal organs. Sarcoma is a cancer that begins in bone, cartilage, fat, muscle, blood vessels, or other connective or supportive tissue. Leukemia is a cancer that starts in blood-forming tissue such as the bone marrow, and causes large numbers of abnormal blood cells to be produced and enter the blood. Lymphoma and multiple myeloma are cancers that begin in the cells of the immune system. Central nervous system cancers are cancers that begin in the tissues of the brain and spinal cord. Also called malignancy.
Preview- You can notice, yoshinobu Kanda (The University of Tokyo Hospital, Japan) described a series of seven patients with advanced pancreatic cancer, who received a conditioning regimen based on gemcitabine, busulfan, and fludarabine and allograft from a HLA-compatible sibling donor; he observed two minor responses of short duration, and a median survival of 229 days. Allograft is the transplant of an organ, tissue, or cells from one individual to another individual of the same species who is not an identical twin. Pancreatic cancer is a disease in which malignant (cancer) cells are found in the tissues of the pancreas. Also called exocrine cancer. Fludarabine is the active ingredient in a drug used to treat B-cell chronic lymphocytic leukemia (CLL) that has not responded to treatment with other anticancer drugs or that has gotten worse. Fludarabine blocks cells from making DNA and may kill cancer cells. It is a type of purine antagonist and a type of ribonucleotide reductase inhibitor. Median is a statistics term. The middle value in a set of measurements. Busulfan is an anticancer drug that belongs to the family of drugs called alkylating agents. Sibling is a person`s brother or sister who has the same parents. Pancreatic, having to do with the pancreas. Median survival is the length of time from either the date of diagnosis or the start of treatment for a disease, such as cancer, that half of the patients in a group of patients diagnosed with the disease are still alive. In a clinical trial, measuring the median survival is one way to see how well a new treatment works. Also called median overall survival. HLA is a type of molecule found on the surface of most cells in the body. HLAs play an important part in the body`s immune response to foreign substances. They make up a person`s tissue type, which varies from person to person. HLA tests are done before a donor stem cell or organ transplant, to find out if tissues match between the donor and the person receiving the transplant. Also called human leukocyte antigen and human lymphocyte antigen. Gemcitabine is the active ingredient in a drug that is used to treat pancreatic cancer that is advanced or has spread. It is also used with other drugs to treat breast cancer that has spread, advanced ovarian cancer, and non-small cell lung cancer that is advanced or has spread. It is also being studied in the treatment of other types of cancer. Gemcitabine blocks the cell from making DNA and may kill cancer cells. It is a type of antimetabolite
- Finally, it is often discovered that, myeloablation is the result of an intensive conditioning regimen in which the bone marrow cells are destroyed. The goal of using a reduced intensity conditioning regimen is to decrease the transplant-related complications, toxicity and mortality. However, since myeloablation may not be achieved with this approach, the risk of rejecting the transplant may be higher compared to a full-intensity (myeloablative) conditioning regimen. Bone marrow is the soft, sponge-like tissue in the center of most bones. It produces white blood cells, red blood cells, and platelets. Toxicity is the extent to which something is poisonous or harmful. Mortality is the state of being mortal (destined to die). Mortality also refers to the death rate, or the number of deaths in a certain group of people in a certain period of time. Mortality may be reported for people who have a certain disease, live in one area of the country, or who are of a certain gender, age, or ethnic group. Myeloablation is a severe form of myelosuppression. Myelosuppression is a condition in which bone marrow activity is decreased, resulting in fewer red blood cells, white blood cells, and platelets. It is a side effect of some cancer treatments. Also called severe myelosuppression.
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