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What is cancer autologous bone marrow transplantation?
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- cancer autologous bone marrow transplantation
Autologous bone marrow transplantation is a procedure in which bone marrow is removed from a person, stored, and then given back to the person after intensive treatment. Transplantation is a surgical procedure in which tissue or an organ is transferred from one area of a person`s body to another area, or from one person (the donor) to another person (the recipient). Bone marrow transplantation is a procedure to replace bone marrow that has been destroyed by treatment with high doses of anticancer drugs or radiation. Transplantation may be autologous (an individual`s own marrow saved before treatment), allogeneic (marrow donated by someone else), or syngeneic (marrow donated by an identical twin). Autologous, taken from an individual`s own tissues, cells, or DNA. Cancer is a term for diseases in which abnormal cells divide without control and can invade nearby tissues. Cancer cells can also spread to other parts of the body through the blood and lymph systems. There are several main types of cancer. Carcinoma is a cancer that begins in the skin or in tissues that line or cover internal organs. Sarcoma is a cancer that begins in bone, cartilage, fat, muscle, blood vessels, or other connective or supportive tissue. Leukemia is a cancer that starts in blood-forming tissue such as the bone marrow, and causes large numbers of abnormal blood cells to be produced and enter the blood. Lymphoma and multiple myeloma are cancers that begin in the cells of the immune system. Central nervous system cancers are cancers that begin in the tissues of the brain and spinal cord. Also called malignancy. Bone marrow is the soft, sponge-like tissue in the center of most bones. It produces white blood cells, red blood cells, and platelets. Autologous bone marrow is in transplantation, refers to a person`s own bone marrow. Bone marrow is the soft, sponge-like tissue in the center of most large bones that produces white blood cells, red blood cells, and platelets.
Preview- It has been found that, aetna considers high-dose chemotherapy (HDC) with autologous bone marrow transplant (ABMT (Autologous Bone Marrow Transplant)) or peripheral stem cell transplant for the treatment of persons with relapsed or primary refractory (see Note below) non-Hodgkin`s lymphoma (NHL) medically necessary if the person meets the transplanting institution`s protocol eligibility criteria. Peripheral stem cell is an immature cell found circulating in the bloodstream. New blood cells develop from peripheral stem cells. NHL, any of a large group of cancers of lymphocytes (white blood cells). NHLs can occur at any age and are often marked by lymph nodes that are larger than normal, fever, and weight loss. There are many different types of NHL. These types can be divided into aggressive (fast-growing) and indolent (slow-growing) types, and they can be formed from either B-cells or T-cells. B-cell NHLs include Burkitt lymphoma, chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), diffuse large B-cell lymphoma, follicular lymphoma, immunoblastic large cell lymphoma, precursor B-lymphoblastic lymphoma, and mantle cell lymphoma. T-cell NHLs include mycosis fungoides, anaplastic large cell lymphoma, and precursor T-lymphoblastic lymphoma. Lymphomas that occur after bone marrow or stem cell transplantation are usually B-cell NHLs. Prognosis and treatment depend on the stage and type of disease. Also called non-Hodgkin lymphoma. Stem cell is a cell from which other types of cells develop. For example, blood cells develop from blood-forming stem cells. Protocol is a detailed plan of a scientific or medical experiment, treatment, or procedure. In clinical trials, it states what the study will do, how it will be done, and why it is being done. It explains how many people will be in the study, who is eligible to take part in it, what study drugs or other interventions will be given, what tests will be done and how often, and what information will be collected. Refractory is in medicine, describes a disease or condition that does not respond to treatment. Cell is the individual unit that makes up the tissues of the body. All living things are made up of one or more cells. Eligibility criteria is in clinical trials, requirements that must be met for an individual to be included in a study. These requirements help make sure that patients in a trial are similar to each other in terms of specific factors such as age, type and stage of cancer, general health, and previous treatment. When all participants meet the same eligibility criteria, it gives researchers greater confidence that results of the study are caused by the intervention being tested and not by other factors. High-dose chemotherapy is an intensive drug treatment to kill cancer cells, but that also destroys the bone marrow and can cause other severe side effects. High-dose chemotherapy is usually followed by bone marrow or stem cell transplantation to rebuild the bone marrow. Chemotherapy, treatment with drugs that kill cancer cells. Stem cell transplant is a method of replacing immature blood-forming cells in the bone marrow that have been destroyed by drugs, radiation, or disease. Stem cells are injected into the patient and make healthy blood cells. A stem cell transplant may be autologous (using a patient`s own stem cells that were saved before treatment), allogeneic (using stem cells donated by someone who is not an identical twin), or syngeneic (using stem cells donated by an identical twin). Lymphoma, cancer that begins in cells of the immune system. There are two basic categories of lymphomas. One kind is Hodgkin lymphoma, which is marked by the presence of a type of cell called the Reed-Sternberg cell. The other category is non-Hodgkin lymphomas, which includes a large, diverse group of cancers of immune system cells. Non-Hodgkin lymphomas can be further divided into cancers that have an indolent (slow-growing) course and those that have an aggressive (fast-growing) course. These subtypes behave and respond to treatment differently. Both Hodgkin and non-Hodgkin lymphomas can occur in children and adults, and prognosis and treatment depend on the stage and the type of cancer.
- It is often discovered that, autologous bone marrow transplantation for low-grade non-Hodgkins lymphoma The European Bone Marrow Transplant Group experience.
- For instance, autologous bone marrow transplantation for patients with non-Hodgkin`s lymphoma and CNS (Central Nervous System) involvement Those transplanted with active CNS (Central Nervous System) disease have a poor outcome -- a report by the European Bone Marrow Transplant Lymphoma Registry. CNS is the brain and spinal cord. Also called central nervous system. Outcome is a specific result or effect that can be measured. Examples of outcomes include decreased pain, reduced tumor size, and improvement of disease.
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