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What is cancer PDGF?
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- cancer pdgf
PDGF is a family of molecules released from platelets (tiny pieces of cells that are found in the blood and that help the blood clot). Forms of PDGF help to heal wounds and to repair damage to blood vessel walls. They also help blood vessels grow. Also called platelet-derived growth factor. Cancer is a term for diseases in which abnormal cells divide without control and can invade nearby tissues. Cancer cells can also spread to other parts of the body through the blood and lymph systems. There are several main types of cancer. Carcinoma is a cancer that begins in the skin or in tissues that line or cover internal organs. Sarcoma is a cancer that begins in bone, cartilage, fat, muscle, blood vessels, or other connective or supportive tissue. Leukemia is a cancer that starts in blood-forming tissue such as the bone marrow, and causes large numbers of abnormal blood cells to be produced and enter the blood. Lymphoma and multiple myeloma are cancers that begin in the cells of the immune system. Central nervous system cancers are cancers that begin in the tissues of the brain and spinal cord. Also called malignancy.
Preview- It is clear that, fidler, I have worked to develop a clinical/translational research program designed to test new therapies preclinically and then rapidly introduce them to the clinic to be studied in a scientific fashion using surrogate endpoints of tissue biopsy and imaging studies. We have now developed and perfected a working orthotopic model of human lung cancer (adenocarcinoma, squamous and small cell), which we are using to study the effects (both at the macroscopic and molecular level) of several compounds, which could impact lung cancer therapy, including PKI-166 (and EGFR antagonist), ZD6474, and STI-571 (an inhibitor of CKIT and the PDGF receptor), working in close collaboration with the laboratory of Doctor Michael S. Lung cancer, cancer that forms in tissues of the lung, usually in the cells lining air passages. The two main types are small cell lung cancer and non-small cell lung cancer. These types are diagnosed based on how the cells look under a microscope. Antagonist is in medicine, a substance that stops the action or effect of another substance. For example, a drug that blocks the stimulating effect of estrogen on a tumor cell is called an estrogen receptor antagonist. EGFR is the protein found on the surface of some cells and to which epidermal growth factor binds, causing the cells to divide. It is found at abnormally high levels on the surface of many types of cancer cells, so these cells may divide excessively in the presence of epidermal growth factor. Also called epidermal growth factor receptor, ErbB1, and HER1. Biopsy is the removal of cells or tissues for examination by a pathologist. The pathologist may study the tissue under a microscope or perform other tests on the cells or tissue. There are many different types of biopsy procedures. The most common types include: (1) incisional biopsy, in which only a sample of tissue is removed; (2) excisional biopsy, in which an entire lump or suspicious area is removed; and (3) needle biopsy, in which a sample of tissue or fluid is removed with a needle. When a wide needle is used, the procedure is called a core biopsy. When a thin needle is used, the procedure is called a fine-needle aspiration biopsy. Cell is the individual unit that makes up the tissues of the body. All living things are made up of one or more cells. Imaging is in medicine, a process that makes pictures of areas inside the body. Imaging uses methods such as x-rays (high-energy radiation), ultrasound (high-energy sound waves), and radio waves. Therapy, treatment. Tissue is a group or layer of cells that work together to perform a specific function. Translational research is a term used to describe the process by which the results of research done in the laboratory are used to develop new ways to diagnose and treat disease. Receptor is a molecule inside or on the surface of a cell that binds to a specific substance and causes a specific effect in the cell. Clinical, having to do with the examination and treatment of patients. ZD6474 is a drug used to treat medullary thyroid cancer that has spread to other parts of the body and cannot be treated by surgery. It is also being studied in the treatment of other types of cancer. ZD6474 prevents the growth of new blood vessels that tumors need to grow. It also blocks enzymes needed for cell growth and may kill cancer cells. It is a type of antiangiogenesis agent and a type of tyrosine kinase inhibitor. Also called Caprelsa and vandetanib. Orthotopic is in medicine, refers to something that occurs in the normal or usual place in the body. It is often used to describe tissue or an organ that is transplanted into its normal place in the body. Lung, one of a pair of organs in the chest that supplies the body with oxygen, and removes carbon dioxide from the body. Adenocarcinoma, cancer that begins in cells that line certain internal organs and that have gland-like (secretory) properties.
- It appears to be, in contrast, we have been unable to detect expression of either PDGF receptor by RT-PCR or western blot analysis using validated antibodies, nor growth inhibition by imatinib, during careful analysis of three of the cervical cancer cell lines used in this study [49] (Figure S8). Moreover, and consistent with our analyses, meta-analysis of the gene expression profile of human cervical cancer cell lines in the National Center for Biotechnology Information (NCBI) GEO database revealed no detectable transcripts for either of the PDGF receptors in three separate studies of HeLa cells (unpublished data), one of the cell lines stated to express PDGFR in the report in question [49]. Our data, as well as that from the Human Protein Atlas project, from analysis of human cervical cancer cell lines and human tissues are consistent with the more definitive analysis in the mouse, indicating that PDGF receptors are predominantly expressed by stromal fibroblasts and pericytes. PCR is a laboratory method used to make many copies of a specific DNA sequence. Also called polymerase chain reaction. Meta-analysis is a process that analyzes data from different studies done about the same subject. The results of a meta-analysis are usually stronger than the results of any study by itself. Protein is a molecule made up of amino acids. Proteins are needed for the body to function properly. They are the basis of body structures, such as skin and hair, and of other substances such as enzymes, cytokines, and antibodies. Gene expression profile, information about all messenger RNAs that are made in various cell types. A gene expression profile may be used to find and diagnose a disease or condition and to see how well the body responds to treatment. Gene expression profiles may be used in precision medicine. Gene is the functional and physical unit of heredity passed from parent to offspring. Genes are pieces of DNA, and most genes contain the information for making a specific protein. Cervical cancer, cancer that forms in tissues of the cervix (the organ connecting the uterus and vagina). It is usually a slow-growing cancer that may not have symptoms but can be found with regular Pap tests (a procedure in which cells are scraped from the cervix and looked at under a microscope). Cervical cancer is almost always caused by human papillomavirus (HPV) infection. Analysis is a process in which anything complex is separated into simple or less complex parts. Cervical, relating to the neck, or to the neck of any organ or structure. Cervical lymph nodes are located in the neck. Cervical cancer refers to cancer of the uterine cervix, which is the lower, narrow end (the neck ) of the uterus. Gene expression is the process by which a gene gets turned on in a cell to make RNA and proteins. Gene expression may be measured by looking at the RNA, or the protein made from the RNA, or what the protein does in a cell.
- It seems to be, however, relatively little is known about the role that the stroma plays in the neoplastic progression of cervical cancer or how it is regulated other than that a protein called platelet-derived growth factor (PDGF), which is made by the tumor cells, might be involved in its formation. In this study, the researchers have used a mouse model of cervical cancer (HPV/E2 mice) to investigate PDGF signaling in the tumor stroma. HPV/E2 mice develop CINs before they are three months old; by five months of age, 90% of them have invasive cervical cancer. Progression is in medicine, the course of a disease, such as cancer, as it becomes worse or spreads in the body. Invasive cervical cancer, cancer that has spread from the surface of the cervix to tissue deeper in the cervix or to other parts of the body. Growth factor is a substance made by the body that functions to regulate cell division and cell survival. Some growth factors are also produced in the laboratory and used in biological therapy. Platelet is a tiny piece of cell that is made by breaking off of a large cell in the bone marrow. Platelets are found in the blood and spleen. They help form blood clots to slow or stop bleeding, and to help wounds heal. Also called thrombocyte. Mouse model is the use of special strains of mice to study a human disease or condition, and how to prevent and treat it. HPV is a type of virus that can cause abnormal tissue growth (for example, warts) and other changes to cells. Infection for a long time with certain types of HPV can cause cervical cancer. HPV may also play a role in some other types of cancer, such as anal, vaginal, vulvar, penile, oropharyngeal, and squamous cell skin cancers. Also called human papillomavirus. Tumor is an abnormal mass of tissue that results when cells divide more than they should or do not die when they should. Tumors may be benign (not cancer), or malignant (cancer). Also called neoplasm. Platelet-derived growth factor is a family of molecules released from platelets (tiny pieces of cells that are found in the blood and that help the blood clot). Forms of platelet-derived growth factor help to heal wounds and to repair damage to blood vessel walls. They also help blood vessels grow. Also called PDGF.
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