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What is cancer multiple endocrine adenomatosis type 2A?
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- cancer multiple endocrine adenomatosis type
Multiple endocrine adenomatosis is a rare, inherited disorder that affects the endocrine glands and can cause tumors in the parathyroid and pituitary glands and the pancreas. These tumors are usually benign (not cancer). They cause the glands to secrete high levels of hormones, which can lead to other medical problems, such as kidney stones, fertility problems, and severe ulcers. In some cases, tumors inside the pancreas can become malignant (cancer). Also called MEN1 syndrome, multiple endocrine neoplasia type 1 syndrome, and Wermer syndrome. Endocrine, refers to tissue that makes and releases hormones that travel in the bloodstream and control the actions of other cells or organs. Some examples of endocrine tissues are the pituitary, thyroid, and adrenal glands. Cancer is a term for diseases in which abnormal cells divide without control and can invade nearby tissues. Cancer cells can also spread to other parts of the body through the blood and lymph systems. There are several main types of cancer. Carcinoma is a cancer that begins in the skin or in tissues that line or cover internal organs. Sarcoma is a cancer that begins in bone, cartilage, fat, muscle, blood vessels, or other connective or supportive tissue. Leukemia is a cancer that starts in blood-forming tissue such as the bone marrow, and causes large numbers of abnormal blood cells to be produced and enter the blood. Lymphoma and multiple myeloma are cancers that begin in the cells of the immune system. Central nervous system cancers are cancers that begin in the tissues of the brain and spinal cord. Also called malignancy.
Preview- It`s been discovered that, MEN (multiple endocrine neoplasia) type 2 syndrome is an inherited disease characterized by medullary thyroid carcinoma, pheochromocytoma, hyperparathyroidism and/or developmental anomalies. Germ-line mutations of the RET proto-oncogene have recently been identified as the underlying cause of the syndrome. Hyperparathyroidism is a condition in which the parathyroid gland (one of four pea-sized organs found on the thyroid) makes too much parathyroid hormone. This causes a loss of calcium from the bones and an increased level of calcium in the blood. Symptoms include bone pain and kidney problems. Thyroid is a gland located beneath the larynx (voice box) that makes thyroid hormone and calcitonin. The thyroid helps regulate growth and metabolism. Also called thyroid gland. Germ is a bacterium, virus, or other microorganism that can cause infection and disease. Proto-oncogene is a gene involved in normal cell growth. Mutations (changes) in a proto-oncogene may cause it to become an oncogene, which can cause the growth of cancer cells. Inherited, transmitted through genes that have been passed from parents to their offspring (children). Pheochromocytoma, tumor that forms in the center of the adrenal gland (gland located above the kidney) that causes it to make too much adrenaline. Pheochromocytomas are usually benign (not cancer) but can cause high blood pressure, pounding headaches, heart palpitations, flushing of the face, nausea, and vomiting. Syndrome is a set of symptoms or conditions that occur together and suggest the presence of a certain disease or an increased chance of developing the disease. Oncogene is a gene that is a mutated (changed) form of a gene involved in normal cell growth. Oncogenes may cause the growth of cancer cells. Mutations in genes that become oncogenes can be inherited or caused by being exposed to substances in the environment that cause cancer. Carcinoma, cancer that begins in the skin or in tissues that line or cover internal organs. Neoplasia, abnormal and uncontrolled cell growth.
- It`s that, multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder that results in parathyroid, anterior pituitary, and pancreatic and duodenal endocrine tumors in affected individuals. The MEN1 locus is tightly linked to the marker PYGM on chromosome 11q13 ... Chromosome, part of a cell that contains genetic information. Except for sperm and eggs, all human cells contain 46 chromosomes. Anterior is in human anatomy, has to do with the front of a structure, or a structure found toward the front of the body. Locus, specific place where something is located or occurs. It may refer to a specific place on the body (such as an acupuncture point) or the place on a chromosome where a specific gene is found. Marker is a diagnostic indication that disease may develop. Pancreatic, having to do with the pancreas.
- It would appear apparant that, multiple endocrine neoplasia (MEN) type 2 is a rare genetic disorder characterized by an increased risk of developing a specific form of thyroid cancer (medullary thyroid carcinoma) and benign tumors affecting additional glands of the endocrine system. The endocrine system is the network of glands that secrete hormones into the bloodstream where they travel to various areas of the body. Secrete, to form and release a substance. In the body, cells secrete substances, such as sweat that cools the body or hormones that act in other parts of the body. Benign, not cancerous. Benign tumors may grow larger but do not spread to other parts of the body. Also called nonmalignant. Endocrine system is a system of glands and cells that make hormones that are released directly into the blood and travel to tissues and organs all over the body. The endocrine system controls growth, sexual development, sleep, hunger, and the way the body uses food. Thyroid cancer, cancer that forms in the thyroid gland (an organ at the base of the throat that makes hormones that help control heart rate, blood pressure, body temperature, and weight). Four main types of thyroid cancer are papillary, follicular, medullary, and anaplastic thyroid cancer. The four types are based on how the cancer cells look under a microscope. Genetic, inherited; having to do with information that is passed from parents to offspring through genes in sperm and egg cells.
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