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What is cancer castration?
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- cancer castration
Castration, removal or destruction of the testicles or ovaries using radiation, surgery, or drugs. Medical castration refers to the use of drugs to suppress the function of the ovaries or testicles. Cancer is a term for diseases in which abnormal cells divide without control and can invade nearby tissues. Cancer cells can also spread to other parts of the body through the blood and lymph systems. There are several main types of cancer. Carcinoma is a cancer that begins in the skin or in tissues that line or cover internal organs. Sarcoma is a cancer that begins in bone, cartilage, fat, muscle, blood vessels, or other connective or supportive tissue. Leukemia is a cancer that starts in blood-forming tissue such as the bone marrow, and causes large numbers of abnormal blood cells to be produced and enter the blood. Lymphoma and multiple myeloma are cancers that begin in the cells of the immune system. Central nervous system cancers are cancers that begin in the tissues of the brain and spinal cord. Also called malignancy.
Preview- It really is clear that, recent studies suggest that these activities are due to the generation of constitutively active AR splice variants, but the mechanisms by which these splice variants could mediate such effects are not fully understood. Here we have identified what we believe to be a novel human AR splice variant in which exons 5, 6, and 7 are deleted (ARv567es) and demonstrated that this variant can contribute to cancer progression in human prostate cancer xenograft models in mice following castration. We determined that, in human prostate cancer cell lines, ARv567es functioned as a constitutively active receptor, increased expression of full-length AR (ARfl), and enhanced the transcriptional activity of AR. Progression is in medicine, the course of a disease, such as cancer, as it becomes worse or spreads in the body. Cell is the individual unit that makes up the tissues of the body. All living things are made up of one or more cells. Prostate is a gland in the male reproductive system. The prostate surrounds the part of the urethra (the tube that empties the bladder) just below the bladder, and produces a fluid that forms part of the semen. Xenograft is the transplant of an organ, tissue, or cells to an individual of another species. Receptor is a molecule inside or on the surface of a cell that binds to a specific substance and causes a specific effect in the cell. Prostate cancer, cancer that forms in tissues of the prostate (a gland in the male reproductive system found below the bladder and in front of the rectum). Prostate cancer usually occurs in older men.
- One can conclude that, another mechanism for AR-regulated prostate cancer progression following castration is an alteration in AR protein. This alteration has been reported to occur by genomic mutations: either ligand-dependent activating mutations or ligand-independent activating mutations (12). Alteration is a change resulting in something that is different from the original. Protein is a molecule made up of amino acids. Proteins are needed for the body to function properly. They are the basis of body structures, such as skin and hair, and of other substances such as enzymes, cytokines, and antibodies.
- It`s been discovered that, progression of prostate cancer following castration is associated with increased androgen receptor (AR) expression and signaling despite AR blockade. Recent studies suggest that these activities are due to the generation of constitutively active AR splice variants, but the mechanisms by which these splice variants could mediate such effects are not fully understood. Androgen is a type of hormone that promotes the development and maintenance of male sex characteristics.
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